Lambda Light Chain Disease Survival Rates

My wife has stage 3 light chain myeloma and the published 29 month expectancy scared me a lot.

Lambda light chain disease survival rates.

I was seeing him every 6 months to monitor cll. Ninety seven patients with light chain disease lcd were studied. 57 of patients developed uremia and 59 of patients died. Light chain deposition disease lcdd patients have a very high risk of recurrence of the monoclonal kappa or lambda chain deposition in the graft.

Monoclonal immunoglobulin deposition disease is a group of multisystem disorders characterized by deposition of monoclonal immunoglobulin light or heavy chains in various organs. Ninety seven patients with light chain disease lcd were studied. The largest series published so far has reported after a median follow up of 27 months. The median survival from diagnosis was 30 mo for 52 patients with kappa lcd and 10 mo for 45 patients with lambda lcd p less than 0 0007.

The prognostic factors are age associated multiple myeloma and extrarenal light chain deposition. Until i realized that this number is based on data from 10 to 15 years ago which number is based on survival rates and therapies in use around 2000 a d. The survival of the remaining patients with kappa lcd was still. A lower proportion of kappa lcd patients 15 7 than lambda lcd patients 42 2 died within the first 6 mo after diagnosis.

61 however a review of the era edta registry reported that the mean survival in 35 kt patients with lcdd was 9 6 years. Median survival for patients with light chain deposition disease lcdd is about 4 years. The median survival from diagnosis was 30 mo for 52 patients with κ lcd and 10 mo f. Light chain deposit disease lcdd is an uncommon monoclonal gammopathy which should be considered carefully in patients who have both renal disease and a lymphoplasmacytic disorder capable of producing monoclonal light chains myeloma macroglobulinaemia lymphoma chronic lymphatic leukaemia 2 4 the diagnosis is straightforward when monoclonal light chains are present.

1 the most commonly diagnosed monoclonal immunoglobulin deposition disease is light chain deposition disease lcdd in which monoclonal immunoglobulin light chains lcs are deposited the others being heavy chain. The median survival from diagnosis was 30 mo for 52 patients with kappa lcd and 10 mo for 45 patients with lambda lcd p less than 0 0007. I didn t have much energy over the weekend but i did improve and by the time an appointment with my hematologist came up on tuesday i considered cancelling it. A lower proportion of kappa lcd patients 15 7 than lambda lcd patients 42 2 died within the first 6 mo after diagnosis.

The median survival from diagnosis was 30 mo for 52 patients with kappa lcd and 10 mo for 45 patients with lambda lcd p less than 0 0007. 60 in a study on 7 patients 5 71 recurred after a mean period of 33 months with a contemporaneous poor prognosis. I have lambda light chain myeloma and my first symptom was an unusual shortness of breath when loading up for a fishing trip on a saturday.